Antiplatelet aggregation activity of diterpene alkaloids …

Six diterpene alkaloids with an atisine-type C(20)-skeleton isolated from the Chinese herbal medicines Spiraea japonica var. acuta and S. japonica var. ovalifolia, as well as eight derivatives of spiramine C and spiradine F were evaluated for the ability to inhibit aggregation of rabbit platelets induced by arachidonic acid, ADP, and platelet …

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Antiplatelet actions of aporphinoids from formosan plants

Ke3nvords: Alkaloids, Anticoagulants, Natural products, Plants Platelets play an important role in the hemostatic process, and their aggregation can cause arterial thrombosis. Accordingly, compounds with antiplatelet activity …

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A Review of Antiplatelet Activity of Traditional Medicinal …

2.1. COX-1 Inhibitor (Aspirin) Aspirin is a prototypic antiplatelet agent for treatment of patients with various atherosclerotic diseases [].It exerts its effects by inhibiting the activation of COX-1 enzyme which blocks the synthesis of TxA 2 from arachidonic acid [].Aspirin is more effective in the prevention of arterial thrombosis than venous …

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Plant Alkaloids as Antiplatelet Agent: Drugs of the Future in …

The Alkaloid biosynthesis pathway is specifically involved in the decarboxylation of compounds (Grynkiewicz and Gadzikowska, 2008 ). Medicinal plants are a rich source of alkaloids having antiplatelet and anticoagulant activities. The commonly used antiplatelet, aspirin, originated from salicin obtained from willow plant …

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Current update on herbal sources of antithrombotic …

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WEBAcquired data showed that A. atroviolaceum exerted a maximum antiplatelet aggregation effect compared to other allium species . Moreover, the …

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The medicinal and pharmaceutical importance of Dendrobium species

Plants of the Dendrobium genus, one of the largest in the Orchidaceae, manifest a diversity of medicinal effects encompassing antiangiogenic, immunomodulating, antidiabetic, cataractogenesis-inhibiting, neuroprotective, hepatoprotective, anti-inflammatory, antiplatelet aggregation, antifungal, antibacterial, antiherpetic, …

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Current update on herbal sources of antithrombotic …

This review presents a compilation of plants investigated for antiplatelet and anticoagulation recently and enumerates their possible lead compounds responsible for …

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Bioactive Natural Compounds with Antiplatelet and …

The analysis of the literature data selected demonstrates that many plants' bioactive compounds show antiplatelet and anticoagulant activity that make them potential candidates to be used as new natural compounds able to interfere with both primary and …

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Novel antiplatelet constituents from formosan moraceous plants

Sixteen constituents from Formosan Moraceous plants were tested for their antiplatelet activities in rabbit platelet suspension and human platelet-rich plasma. Cycloartocarpin A, cycloheterophyllin, broussochalcone A, kazinol A, broussoaurone A, and broussoflavonol F showed strong inhibition of arachidonic acid (AA)-induced platelet aggregation.

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Evaluation of Anti-Platelet Aggregation Effect of Some

Plant materials have long been used as traditional medicines for the treatment of a number of ailments and diseases . Scientific search for new therapeutic agents is strongly supported by epidemiological studies on medicinal plants. ... Although there are citations of antiplatelet aggregation activity of some Allium species (15-17), there are ...

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[Studies on antiplatelet aggregation and anticoagulant action …

Antiplatelet aggregation and anticoagulant action of processed products with vinegar is the most powerful. [Studies on antiplatelet aggregation and anticoagulant action of Curcuma phaeocaulis] Zhong Yao Cai. 2000 Apr;23(4):212-3. ... Plants, Medicinal / …

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Exploring the Therapeutic Potential: Antiplatelet and …

Conclusion: These results could contribute to the validation of the medical use of these extracts that exert an antiplatelet effect to treat hemostatic and thrombotic disorders. Keywords: Medicinal plants of Morocco, aqueous extract, antiplatelet aggregation, antioxidant activity, phytochemical analysis, secondary metabolites.

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Coumarins and antiplatelet aggregation constituents from …

Studies searching for antiplatelet aggregation principles from Formosan plants revealed that the methanol extract of the root of this plant, collected in Lanyu Island, exhibited strong inhibitory activity on platelet aggregation in vitro. ... *P < 0.05; **P < 0.01; ***P < 0.001 as compared with the respective control. Coumarins and Antiplatelet ...

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Coumarins and antiplatelet aggregation constituents from Formosan

Coumarins and antiplatelet aggregation constituents from Formosan Peucedanum japonicum Phytochemistry. 1996 Feb;41(2):525-30. doi: 10.1016/0031-9422(95)00625-7. ... Plant Extracts / chemistry* Plants, Medicinal / chemistry* Platelet Aggregation Inhibitors / …

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An Overview of Medicinal Plants as Potential Anti-Platelet Agents

This systemic review mainly is focused on herbal plants as antiplatelet in various traditional medicines and explores the herbal plant, isolated active constituent and formulation with antiplatelet activity. ... Phytochemistry, 67(8), 2006, 824-29. Chang FR, Wei JL, Teng CM, and Wu YC, Antiplatelet aggregation constituents from Annona …

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Antiplatelet aggregation effects of phenanthrenes from …

In the antiplatelet aggregation assay, phenanthrenes 1 and 2 showed potential antiplatelet activity. We have reported and discussed here the antiplatelet aggregation properties of the eleven naturally-occurring phenanthrenes (1-2 and 9-17) isolated from the underground part of the plant and eighteen chemically synthesized phenanthrenes (18-35).

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Phenolic Bioactives as Antiplatelet Aggregation …

Cardiovascular diseases (CVD) are one of the main causes of mortality in the world. The development of these diseases has a specific factor—alteration in blood platelet activation. It has been shown …

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Antiplatelet Aggregation Coumarins from the Leaves of

Of these, three compounds were reported to exhibit significant antiplatelet aggregation induced by arachidonic acid (AA) and collagen . In the continuing phytochemical investigation, two coumarins, minumicroline acetonide ( 1 ) [ 5, 6 ] and epimurpaniculol senecioate ( 2 ), were isolated from the methanoic extracts of the leaves …

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Natural Products with Antiplatelet Action

This review showed that several plants and/or compounds exhibit anti-platelet activity, and are therefore potential research targets for developing drugs to treat diseases related to aggregation disorders. Natural Products with Antiplatelet Action ... components, which are directly related to the antiplatelet activity of the plant, such as ...

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Antiplatelet aggregation activity of diterpene alkaloids from

It is the first report that C 20 -diterpene alkaloids inhibit PAF-induced platelet aggregation. However, spiramine C1 concentration-dependently inhibited platelet aggregation induced by PAF, ADP and arachidonic acid with IC 50 values of 30.5±2.7, 56.8±8.4 and 29.9±9.9 μM, respectively, suggesting a non-selective antiplatelet …

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Antiplatelet activity of Lampaya medicinalis Phil. in human …

Plants are an important source of antithrombogenic compounds and have been considered as an alternative therapy for those diseases associated with increased platelet aggregation. Nevertheless, the efficacy of plants and their metabolites as potential therapeutic antiplatelet agents needs further clarification [32].

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Medicinal Herbals with Antiplatelet Properties Benefit in …

The common name for this plant is ginger, a traditional medicine with a carminative effect. This herb has been investigated for its antiplatelet properties. An initial study done on aqueous extract of ginger had shown that it inhibits platelet aggregation induced by AA, adenosine diphosphate, and collagen [ 19 ].

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Regulation of Key Antiplatelet Pathways by Bioactive …

The antiplatelet activity of numerous fruits and vegetables and their multiple mechanisms of action have recently been highlighted. ... Several dietary supplements and plant or fruit extracts have been reported to exert beneficial and protective effects ... and Lupin (Lupinus spp.) extracts on human platelet aggregation. Plant Foods Hum. Nutr ...

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Antithrombotic and antiplatelet effects of plant-derived …

Antithrombotic and antiplatelet effects of plant-derived compounds: a great utility potential for primary, secondary, and tertiary care in the framework of 3P medicine. …

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Flavonoids as potential anti-platelet aggregation agents: …

Consumption of plant-food-derived bioactives, particularly flavonoids, has shown antithrombotic, and cardiovascular protective effects due to its anti-platelet activity. Preclinical and clinical trials have proven that flavonoid-rich plant extracts are protective against the cardiac ailments through anti-platelet aggregation activity.

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Antiplatelet aggregation and platelet activating factor (PAF) …

Nine essential oils, hydrodistilled from different parts of five Goniothalamus species (G. velutinus Airy-Shaw, G. woodii Merr., G. clemensii Ban, G. tapis Miq. and G. tapisoides Mat Salleh) were evaluated for their ability to inhibit platelet aggregation in human whole blood using an electrical impedance method and their inhibitory effects on …

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Antiplatelet Aggregation Effects of Phenanthrenes from …

In the antiplatelet aggregation assay, phenanthrenes 1 and 2 showed potential antiplatelet activity. ... (1-2 and 9-17) isolated from the underground part of the plant and eighteen chemically ...

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Antiplatelet actions of aporphinoids from formosan plants

The latter showed the strongest antiplatelet activity with an IC 50 of 70.4 μM against AA-induced platelet aggregation. Seventeen aporphines were tested for antiplatelet activity. L- (+)-hernovine HCl and 7-hydroxydehydrothalicsimidine strongly inhibited platelet aggregation induced by adenosine 5′-diphosphate (ADP), arachidonic …

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Molecules | Free Full-Text | Antiplatelet …

Interestingly, thepossible acetonide artifact 1 displayed significant antiplatelet aggregation induced not onlyby AA and collagen but also by platelet activating factor (PAF). ... Taiwan, in September 1999, and …

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Plant Alkaloids as Antiplatelet Agent: Drugs of the Future …

Plants primarily use alkaloids to protect themselves from herbivores and diseases. Alkaloids are used in ancient and modern medicines in amounts ranging from 25 to 75%, demonstrating their ...

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Flavonoids as potential anti-platelet aggregation agents: …

Preclinical and clinical trials have proven that flavonoid-rich plant extracts are protective against the cardiac ailments through anti-platelet aggregation activity. This review aims …

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Antiplatelet Medications

Antiplatelet medications divide into oral and parenteral agents, and oral agents subdivide further based on the mechanism of action. Aspirin was the first antiplatelet medication and is a cyclooxygenase inhibitor. ... while PGI2 works by inhibiting platelet aggregation and induces vasodilation, and is mediated by COX-2. Low-dose …

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In vitro antiplatelet aggregation activity of Centella …

Then, exploration of medicinal plants which have cardioprotective activity especially as antiplatelet aggregation agent are needed. One of the medicinal plant, Centella asiatica (L.) Urban, has ...

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Simultaneous screening and analysis of antiplatelet aggregation …

Objective: The antiplatelet aggregation compounds in Rhizoma Corydalis were screened to validate its traditional medicinal use. Material and methods: Total alkaloid extract (TAE) of Rhizoma Corydalis was obtained by refluxing 100 g Rhizoma Corydalis powder with 600 mL 70% ethanol, and purified by acidification (20% HCl) and alkalization (5 M ...

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Anti-inflammatory, Antiplatelet Aggregation, and …

The ethyl acetate extract of an endophyte Epicoccum sorghinum exhibited anti-inflammatory activity at a concentration of <10 μg/mL. By bioassay-guided fractionation, one new compound, named epicorepoxydon A (1), and one unusual bioactive compound, 6-(hydroxymethyl)benzene-1,2,4-triol (6), together with six known compounds, were …

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Studies on triterpenoid glycosides from rhizomes of

Compounds 2―8 were obtained from the plant for the first time. Compounds 3 and 4 displayed good activities against adenosine diphosphate (ADP)-induced platelet aggregation, and compounds 1, 5, 6 and 8 showed moderate activities. Compound 6 exhibited moderate antiplatelet aggregation activity induced by arachidonic acid(AA).

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Natural Products with Antiplatelet Action

Results: Of the main plants discussed in this review, which have antiplatelet activity, some include saffron, garlic, green tea, St. John's wort, ginger, ginkgo biloba, ginseng, and …

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Plant extracts inhibit ADP-induced platelet activation in

Adenosine-5′-diphosphate (ADP) plays a crucial role in platelet activation [1, 2].In addition, platelet hyperactivity is known to be associated with vascular disease and has a key role in haemostasis and thrombosis [3, 4].ADP is considered a weak platelet agonist, since it induces platelet shape change (PSC, an early phase of platelet activation) and …

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Medicinal Plants with Antiplatelet Activity

From this review, it was suggested that medicinal plants with antiplatelet activity mainly belong to the family of Asteraceae, Rutaceae, Fabaceae, Lamiaceae, …

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Evidence and prospective of plant derived flavonoids as antiplatelet …

In traditional medicine, plants are used either whole or as parts (Khan, 2014). Literature reveals the antiplatelet activity of common edible plant products as apples, strawberry, tomatoes, spinach, among others (Bondonno et al., 2012, Alvarez-Suarez et al., 2014, Alarcòn et al., 2014, Fuentes et al., 2013).

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